Comparative Carcinogenicity of Ionizing Radiation and by National Council on Radiation Protection and Measurements

By National Council on Radiation Protection and Measurements

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22. 23. 24. 25. 26. 27. 28. 29. 30. 3 1. 32. 33: 34. 35. 36. 37. 38. 39.. Acetamide* Acridheorange Acriflaviniumchloride Actimomycins* Adriamycin Aldrin Amaranth 5Aminoacenaphthene pAminoazobenzene* ~Aminoazotoluene* pAminobenzoic acid 40. 41. 2-Amino5-(5-nitre2-furyl~ 48. 49. 50. 5 1. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 1,3,4thiadiazole* 4Amino2-nitrephenol Amitrole* Aniline Anthradic acid Apholate Ammite* Arsenic Moxide Aumthioglucose* Azaserine* Axiridine* 2-(1-Aziridhyl)-ethanol* Aziridyl benzoquinon@ Azobenzene* Barium chromate Benz[a]acridine* Benz[c]acridhe* Benz+]fluoranthene* Benzoljlfluoranthene* Benzo(alpyrene* Bem$ePyreneZ Benzyl chloride* Benzylviolet4B* Beryllium* Beryllium oxide* Beryllium phosphate* BerylliumsulfaW Berylom* 42.

By a similar mechanism, glycosides react with various glycosidases, resulting in reactive intermediates capable of binding covalently with nucleic acid and protein. 3) to form reactive intermediates. Some chemicals by their inherent molecular properties possess a high miox potential. o-Aminophenol, for example, is capable of oxidizing ferrohemoglobin to ferrihemoglobin. Nitrates also cause methe moglobinemia. Such oneelectron chemical reactions may play a role in mutagenesis. 4 PHARMACOKINETICS 1 43 Perhaps only a few enzymes (or none) exist in the body solely to take care of foreign chemicals.

Monoamine (includingcatecholamine)oxidations B. Reductions (Phase I metaboliem) 1. AzoFeductions 2. Nitro reductions 3. h e oxide reductions 4. N-hydroxyl reductions 5. Quinone reductions 6. Carbonyl sulfide reduction by carbonic anhydrase 7. Reductions of transition metal ion . d t e C. Hydrolyses (Phase I metabolism) 1. Hydrolyses of esters 2. Hydrolyses of amides 3. Hydrolyses of peptides D. Conjugations (PhaseI1 metabolism) 1. Glucuronidations 2. Sulfate wnjugations 3. Glutathione conjugations 4.

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