By Linda A. Felton, James W. McGinity
This hugely praised publication offers an in-depth research of actual and chemical homes and purposes of aqueous-based polymeric coatings-covering covered dosage types, movie defects, and polymer characterization. New chapters on plastisizers and their functions in pharmaceutical coatings, adhesion of polymeric motion pictures to sturdy substrates, and the effect of pigments on homes of the polymeric coating structures are integrated during this 3rd version. also, this name presents new fabric on polymer interactions with medicinal drugs and excipients and actual getting older of polymeric movies.
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Extra info for Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences)
To distinguish among these mechanisms, the release rate was studied as a function of coating thickness, plasticizer content, and osmotic pressure in the dissolution medium. 21). Release as a function of plasticizer content was studied over the range of 12% to 24% DBS (Fig. 22). At 18% or 24% DBS, the release rates were virtually identical, about 50% in six hours. At 12% DBS, over 80% was released in the first hour, and these results were attributed to the presence of cracks in the coating. Release was also studied as a function of the osmotic pressure in the medium (Fig.
6. Onions A. Films from water-based colloidal dispersions Manuf Chem 1986; 12: 55–59. Frenkel J. Viscous flow of crystalline bodies under the action of surface tension. J Phys 1945; 9(5):385–491. Dillon RE, Matheson LA, Bradford EB. Sintering of synthetic latex particles. J Colloid Sci 1951; 6(2):108–117. Brown GL. Formation of films from polymer dispersions. J Polym Sci 1956; 22(102):423–434. Steward PA. Modification of the Permeability of Polymer Latex Films. D. dissertation, Nottingham Trent University, 1995.
Pseudolatex Dispersions for Controlled Drug Delivery 31 Unanticipated pH-dependent release from aqueous ethylcellulose coatings (38,39) may be attributed to partial coalescence (3). Dressman et al. (40) demonstrated that heating pellets coated with ethylcellulose above the Tg of the film stabilized the release profile with respect to the pH of the test media. Additional studies were conducted (41) to identify changes in the film that would explain the stabilization of the release profile. Curing converted the film from a surface having a finite contact angle to a surface instantly wetted by the dissolution media.