Aqueous polymeric coatings for pharmaceutical dosage forms by Linda A. Felton, James W. McGinity

By Linda A. Felton, James W. McGinity

Aqueous-based movie coating has turn into regimen within the pharmaceutical undefined. This method gets rid of using natural solvents and hence avoids monetary, environmental, and toxicological concerns concerning residual solvents and solvent restoration. Aqueous-based coating, even if, is advanced and lots of variables may possibly impression the ultimate product and its functionality. This fourth variation of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms goals to supply perception into the criteria and parameters that are supposed to be thought of and regulated for the profitable improvement and commercialization of a lined product.

The fourth variation has been revised and elevated to mirror the newest medical developments from the literature. The contributing authors clarify intimately, utilizing illustrated examples, applicable steps to unravel and preferably steer clear of formula, processing, and balance difficulties and to accomplish an optimized dosage shape. alternate names and chemical names of commercially advertised coatings are used in the course of the textual content to aid familiarize the reader with a number of the fabrics to be had for pharmaceutical purposes. This booklet should be a necessary source for an individual within the pharmaceutical operating within the zone of aqueous-based movie coating.

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This is consistent with the presence of surfactants in aqueous polymer dispersions, which would otherwise reduce the driving force implied by the Frenkel equation. 7. “Porous, incompletely coalesced films may be formed from many polymers simply by maintaining, during water evaporation, a temperature lower than a certain critical value. It is observed that for certain polymers a higher temperature exists which is insufficient for coalescence of the porous structure previously formed at a lower temperature, but is adequate for complete coalescence if applied during the entire course of water evaporation.

The size of the holes and porosity due to the leaching of surfactant was reduced if the film was aged or heat-treated before testing. Interdiffusion requires temperatures above the glass transition temperature (Tg) as there will be insufficient polymer segment mobility in the glassy state. Using SANS, Hahn et al. [20,21] demonstrated “massive” interdiffusion of polymer chains from different latex particles during particle coalescence. A 30-fold increase in diffusion coefficients was observed on increasing the “tempering” or curing temperature from 70°C to 90°C.

38). The steep dependency of release rate on osmotic pressure of the medium suggested that osmotically driven release is a major mechanism for release whereas the nonzero intercept indicated some contribution from diffusion mechanisms. 37 Effect of osmotic pressure on PPA∙HCl release profiles (at a 10% coating loading). PPA, phenylpropanolamine. 38 Effect of osmotic pressure difference on PPA∙HCl release rate (at a 10% coating loading). PPA, phenylpropanolamine. 38 Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms 2 μm in diameter, consistent with these mechanisms.

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