By World Health Organization
The guide is an in depth guide giving a step-by-step method of venture the pharmacovigilance of antimalarials. it's meant to be a resource of useful suggestion for pharmacovigilance centres. It presents info on spontaneous reporting of difficult drug reactions as a supplement to different WHO guides. additionally, it presents information on tips on how to behavior cohort occasion tracking, that's a mode of lively defense surveillance amassing details on all adversarial occasions taking place after remedy. It additionally info tips on how to practice causality overview and sign identity, acceptable to either tools of surveillance.
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Extra resources for A Practical Handbook on the Pharmacovigilance of Antimalarial Medicines
Sample text
In addition, the quantitative approaches include: x x x x a description of the selected assessment approach, including monitoring and/or modelling steps, which specify the parameters needed in the assessment; selection of data and specification of any assumptions; execution of calculations; and documentation, interpretation and presentation of results. 2 Nature of uncertainty sources Uncertainty is the lack of knowledge of vital parts that are needed to perform an exposure assessment. Uncertainty can, at least in principle, be reduced by research to obtain necessary or applicable information or data.
If the selected parametric distribution model is an appropriate representation of the data, then the uncertainty in the parameters of the fitted distribution will be based mainly, if not solely, on random sampling error associated primarily with the sample size and variance of the empirical data. Each parameter of the fitted distribution will have its own sampling distribution. Furthermore, any other statistical parameter of the fitted distribution, such as a particular percentile, will also have a sampling distribution.
Inhalation rate, emission rate) or a model component to the total uncertainty in the exposure or risk estimate. In a Tier 2 uncertainty analysis, the analysts usually examine the sensitivity of results to input assumptions by using modified input values. A sensitivity analysis thus performed may provide high, average or low predictions corresponding to the range of values considered for each of the inputs. Typically, these calculations are done for each variable at a time by holding the others constant, but they can also be done jointly by changing all of the inputs.
